SEMAX
$29.99
In stock
- These products are intended for laboratory research purposes only, and are not for human or animal consumption. The products are not intended to diagnose, treat, cure, or prevent any disease. The products should not be used as a food, drug, cosmetic, or other household use.
Description
Semax is a synthetic heptapeptide derived from ACTH fragment 4–10, extended with a Pro-Gly-Pro sequence for enhanced stability and prolonged activity. It penetrates the central nervous system via olfactory transport pathways, upregulates BDNF, and activates TrkB receptor signaling. Widely studied for cognitive enhancement, memory support, and neuroprotection.
Research Overview
Semax is a structurally modified fragment of adrenocorticotropic hormone designed to retain neuroactive properties without the hormonal effects of the parent molecule. Its primary research interest lies in BDNF upregulation and TrkB pathway activation — mechanisms central to neuroplasticity and neural recovery.
Studies have also examined its influence on vascular gene expression, dopaminergic signaling, and immune modulation. Unlike classical psychostimulants, Semax operates through neurotrophic and neuromodulatory mechanisms rather than direct receptor agonism or monoamine release.
Key Features
- Synthetic 7-amino acid heptapeptide (ACTH 4–10 + Pro-Gly-Pro extension)
- Molecular weight: 813.93 Da
- Crosses the blood-brain barrier via olfactory epithelium transport (0.093% CNS penetration)
- Upregulates BDNF ~1.4-fold; activates TrkB receptor signaling
- Modulates dopaminergic, serotonergic, and melanocortin receptor systems
- Half-life: 30 min–2 hours (injectable); peak CNS activity within ~20 minutes
Common Research Uses
- Commonly studied for cognitive enhancement, working memory, and sustained attention
- Researched in relation to BDNF upregulation and neuroplasticity
- Studied in models of ischemic neurological events and post-stroke recovery
- Investigated for mood regulation and stress resilience
- Researched for neuroprotective mechanisms during oxidative or metabolic stress
- Studied for mental endurance in high-demand environments
Product Specifications
- Format: Lyophilized powder
- Vial size: 10mg
- Storage: Freeze at −20°C (lyophilized); refrigerate at 2–8°C after reconstitution; use within 28 days
Disclaimer: For research purposes only. Not for human consumption.
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