MOTS-C
$50.00
Only 1 left in stock
- These products are intended for laboratory research purposes only, and are not for human or animal consumption. The products are not intended to diagnose, treat, cure, or prevent any disease. The products should not be used as a food, drug, cosmetic, or other household use.
Description
MOTS-C is a 16-amino acid mitohormone encoded within the mitochondrial genome, acting as a systemic metabolic regulator through AMPK pathway activation. It mimics key cellular adaptations associated with exercise — including enhanced glucose uptake, improved insulin sensitivity, and increased fat oxidation — and is one of the only known peptides encoded by mitochondrial rather than nuclear DNA.
Research Overview
MOTS-C is produced within the mitochondrial matrix and released as a signaling molecule that travels to peripheral tissues, particularly skeletal muscle. Its primary mechanism involves inhibiting the folate cycle, leading to AICAR accumulation and subsequent AMPK activation — the same metabolic master switch activated by caloric restriction and aerobic exercise.
Under metabolic stress, MOTS-C can also migrate to the cell nucleus, where it binds stress-response transcription factors (NRF2, ATF1, ATF7) to regulate antioxidant defense and energy homeostasis genes. Animal models show approximately 30% improvements in insulin sensitivity alongside enhanced exercise capacity.
Key Features
- 16-amino acid peptide (MRWQEMGYIFYPRKLR) encoded by mitochondrial DNA
- Classified as a mitohormone — secreted by mitochondria to regulate systemic metabolism
- Activates AMPK via the Folate-AICAR signaling axis
- Translocates to the nucleus under metabolic stress; engages NRF2, ATF1, ATF7
- Enhances glucose uptake in skeletal muscle; improves insulin receptor sensitivity
- Half-life: ~4 hours; peak plasma concentration at ~1 hour
Common Research Uses
- Commonly studied for metabolic regulation, insulin sensitivity, and glucose homeostasis
- Researched in relation to AMPK activation and downstream metabolic effects
- Investigated in models of metabolic syndrome, insulin resistance, and type 2 diabetes
- Studied for exercise performance enhancement and skeletal muscle metabolism
- Researched in the context of age-associated metabolic decline and mitochondrial function
Product Specifications
- Format: Lyophilized powder
- Vial size: 10mg or 40mg
- Storage: Freeze at −20°C (lyophilized); refrigerate at 2–8°C after reconstitution; use within 28 days
Disclaimer: For research purposes only. Not for human consumption.
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